van der Leeuw G, Gerrits M J, Terluin B, Numans M E, van der Feltz-Cornelis C M, van der Horst H E, Penninx B W J H, van Marwijk H W J
Faculty of Medicine of the University of Utrecht, Utrecht, The Netherlands; College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA.
Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center and Academic Outpatient Clinic for Affective Disorders, GGZ in Geest, Amsterdam, The Netherlands; Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
J Psychosom Res. 2015 Aug;79(2):117-22. doi: 10.1016/j.jpsychores.2015.03.001. Epub 2015 Mar 11.
Patient encounters for medically unexplained physical symptoms are common in primary health care. Somatization ('experiencing and reporting unexplained somatic symptoms') may indicate concurrent or future disability but this may also partly be caused by psychiatric disorders. The aim of this study was to examine the cross-sectional and longitudinal association between somatization and disability in primary care patients with and without anxiety or depressive disorder.
Data were obtained from 1545 primary care patients, participating in the longitudinal Netherlands Study of Depression and Anxiety (NESDA). Somatization was assessed using the somatization scale of the Four-Dimensional Symptom Questionnaire (4DSQ). Disability was determined by the WHO Disability Assessment Schedule 2.0 (WHO-DAS II). The relationships between somatization and both the total and subdomain scores of the WHO-DAS II were measured cross-sectionally and longitudinally after one year of follow-up using linear regression analysis. We examined whether anxiety or depressive disorder exerted a modifying effect on the somatization-disability association.
Cross-sectionally and longitudinally, somatization was significantly associated with disability. Somatization accounted cross-sectionally for 41.8% of the variance in WHO-DAS disability and, longitudinally, for 31.7% of the variance in disability after one year of follow-up. The unique contribution of somatization to disability decreased to 16.7% cross-sectionally and 15.7% longitudinally, when anxiety and/or depressive disorder was added to the model.
Somatization contributes to the presence of disability in primary care patients, even when the effects of baseline demographic and health characteristics and anxiety or depressive disorder are taken into account.
在初级卫生保健中,因医学上无法解释的身体症状而就诊的患者很常见。躯体化(“体验并报告无法解释的躯体症状”)可能表明存在并发或未来的残疾,但这也可能部分由精神障碍引起。本研究的目的是检验有或无焦虑或抑郁障碍的初级保健患者中,躯体化与残疾之间的横断面和纵向关联。
数据来自1545名参与荷兰抑郁与焦虑纵向研究(NESDA)的初级保健患者。使用四维症状问卷(4DSQ)的躯体化量表评估躯体化。通过世界卫生组织残疾评定量表2.0(WHO-DAS II)确定残疾情况。在随访一年后,使用线性回归分析横断面和纵向测量躯体化与WHO-DAS II总分及各子领域得分之间的关系。我们检验了焦虑或抑郁障碍是否对躯体化-残疾关联产生调节作用。
在横断面和纵向上,躯体化与残疾均显著相关。在横断面上,躯体化占WHO-DAS残疾变异的41.8%,在纵向上,随访一年后占残疾变异的31.7%。当将焦虑和/或抑郁障碍纳入模型时,躯体化对残疾的独特贡献在横断面上降至16.7%,在纵向上降至15.7%。
即使考虑到基线人口统计学和健康特征以及焦虑或抑郁障碍的影响,躯体化仍会导致初级保健患者出现残疾。