Kim Si-Heon, Hur Jae, Jang Jae-Yeon, Park Hae-Sim, Hong Chang Hyung, Son Sang Joon, Chang Ki Jung
From the Department of Preventive Medicine and Public Health (SHK, JYJ); Department of Allergy and Clinical Immunology (HSP); Department of Psychiatry (CHH, SJS, KJC), Ajou University School of Medicine, Suwon; and Cheonan Soo Skin Clinic (JH), Cheonan, South Korea.
Medicine (Baltimore). 2015 Jun;94(23):e949. doi: 10.1097/MD.0000000000000949.
The relationship between atopic dermatitis (AD) and psychological distress has been well established for children and adolescents. However, it is unclear whether this relationship exists in young adults. This study aimed to assess the relationship between AD and psychological distress in young male adults in South Korea. A cross-sectional study was conducted using regional conscription data from 2008 to 2012. A dermatologist diagnosed AD based on historical and clinical features, and determined severity using the eczema area and severity index. A psychiatrist used medical records, an interview, and a psychological test to examine psychological distress (depression, anxiety, and somatization). The relationship between psychological distress and AD was assessed by multivariate logistic regression analyses. Among the 120,508 conscripts, 1517 (1.2%) presented with AD. The odds of having each type of psychological distress were significantly greater for individuals with AD compared with those without AD. The adjusted odds ratios for depression, anxiety, and somatization were 1.79 (95% CI 1.40-2.29), 1.38 (95% CI 1.08-1.76), and 1.75 (95% CI 1.40-2.20), respectively. Moderate-to-severe AD was significantly related to depression and somatization to a greater extent compared with mild AD. Depression, anxiety, and somatization are strongly and independently associated with AD in young adult males. Early treatment of skin inflammation might modify the risk of psychiatric problems. Prospective cohort studies are needed to verify causal relationships.
特应性皮炎（AD）与儿童及青少年心理困扰之间的关系已得到充分证实。然而，这种关系在年轻成年人中是否存在尚不清楚。本研究旨在评估韩国年轻男性成年人中AD与心理困扰之间的关系。采用2008年至2012年的地区征兵数据进行了一项横断面研究。皮肤科医生根据病史和临床特征诊断AD，并使用湿疹面积和严重程度指数确定严重程度。精神科医生使用病历、访谈和心理测试来检查心理困扰（抑郁、焦虑和躯体化）。通过多变量逻辑回归分析评估心理困扰与AD之间的关系。在120508名应征入伍者中，1517人（1.2%）患有AD。与未患AD的人相比，患有AD的人出现每种心理困扰的几率显著更高。抑郁、焦虑和躯体化的调整后比值比分别为1.79（95%CI 1.40-2.29）、1.38（95%CI 1.08-1.76）和1.75（95%CI 1.40-2.20）。与轻度AD相比，中度至重度AD与抑郁和躯体化的相关性更强。在年轻成年男性中，抑郁、焦虑和躯体化与AD密切且独立相关。早期治疗皮肤炎症可能会改变出现精神问题的风险。需要进行前瞻性队列研究以验证因果关系。
