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[接种口服脊髓灰质炎减毒活疫苗儿童的免疫指标]

[Indicators of immunity in children vaccinated with live poliomyelitis vaccine].

作者信息

Kaplan A S, Vasilevskaia N I, Kozhevnikov I N

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1978 Jan(1):115-7.

PMID:204133
Abstract

Serological examination of 1057 children, residents of Leningrad, vaccinated with poliomyelitis vaccine at the appropriate calendar dates according to the scheme, showed the presence of antibodies to the polioviruses in 81.5-99.1% of the cases. There were more serologically negative children against the virus type III, and much less--against the virus type II. The value of the mean geometrical titres somewhat decreased with the advance of the children's age and the time lapse after the vaccination and revaccination. The greatest antibody titres determined were against the poliovirus type II, and the least--against type III. No antibodies against the viruses of types I and III were revealed in case of deficiency against the poliovirus type II. The number of children with the absence of antibodies against the poliovirus of all the types was insignificant.

摘要

对列宁格勒1057名儿童进行血清学检查,这些儿童按照计划在适当的日历日期接种了脊髓灰质炎疫苗,结果显示81.5% - 99.1%的病例体内存在针对脊髓灰质炎病毒的抗体。血清学检测呈阴性的儿童中,针对Ⅲ型病毒的较多,针对Ⅱ型病毒的则少得多。平均几何滴度的值随着儿童年龄的增长以及接种和复种后时间的推移而有所下降。所测定的最高抗体滴度针对Ⅱ型脊髓灰质炎病毒,最低的针对Ⅲ型。在缺乏针对Ⅱ型脊髓灰质炎病毒抗体的情况下,未检测到针对Ⅰ型和Ⅲ型病毒的抗体。所有类型脊髓灰质炎病毒抗体均缺失的儿童数量极少。

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