Hatt Sarah R, Leske David A, Holmes Jonathan M
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.
J AAPOS. 2010 Jun;14(3):221-6. doi: 10.1016/j.jaapos.2010.01.011. Epub 2010 Apr 22.
To compare 2 health-related quality-of-life (HRQOL) instruments: the condition-specific Intermittent Exotropia Questionnaire (IXTQ) and the generic Pediatric Quality of Life Inventory (PedsQL) in children with intermittent exotropia.
Fifty-one children with intermittent exotropia (median, 7 years; range, 5-16 years) were recruited from outpatient clinics with one of their parents. All children completed age-appropriate Child IXTQ (12 items) and Child PedsQL (23 items). Parents completed parallel Proxy IXTQ and Proxy PedsQL (parent assessment of child's HRQOL). Possible scores ranged from 0 to 100 (worst to best HRQOL). Normal thresholds were defined using the 5th percentile in a control group of 47 normal nonstrabismic children. Proportions scoring below normal on each questionnaire were compared. Median scores in intermittent exotropia and control groups also were compared.
More scores were subnormal using Proxy IXTQ than Proxy PedsQL (55% vs 18%, p = 0.0004). When Child questionnaires were used, we found that similar proportions scored below normal (IXTQ 8% vs PedsQL 14%, p = 0.3). Median scores were lower for intermittent exotropia children compared with control patients for Child IXTQ (83 vs 92; p = 0.04), Proxy IXTQ (81 vs 98; p < 0.0001), and Proxy PedsQL (p = 0.04) but not for Child PedsQL (p = 0.3).
The Proxy IXTQ detects reduced HRQOL related to intermittent exotropia more often than the Proxy PedsQL. There were few subnormal scores on Child IXTQ and Child PedsQL. Children with intermittent exotropia scored, on average, lower than control patients on the IXTQ, but most individual scores fell within the normal range. The IXTQ may prove useful for clinical assessment of intermittent exotropia.
比较两种与健康相关的生活质量（HRQOL）评估工具：针对间歇性外斜视的特定疾病间歇性外斜视问卷（IXTQ）和通用的儿童生活质量量表（PedsQL），用于评估间歇性外斜视儿童。
从门诊招募了51名间歇性外斜视儿童（年龄中位数为7岁；范围为5 - 16岁）及其一名家长。所有儿童均完成了适合其年龄的儿童IXTQ（12项）和儿童PedsQL（23项）。家长完成了平行的代理IXTQ和代理PedsQL（家长对孩子HRQOL的评估）。可能的分数范围为0至100（HRQOL最差至最佳）。使用47名正常非斜视儿童组成对照组的第5百分位数定义正常阈值。比较了每个问卷得分低于正常水平的比例。还比较了间歇性外斜视组和对照组的中位数得分。
使用代理IXTQ得出的低于正常水平的分数比代理PedsQL更多（55%对18%，p = 0.0004）。当使用儿童问卷时，我们发现得分低于正常水平的比例相似（IXTQ为8%对PedsQL为14%，p = 0.3）。与对照组患者相比，间歇性外斜视儿童在儿童IXTQ（83对92；p = 0.04）、代理IXTQ（81对98；p < 0.0001）和代理PedsQL（p = 0.04）中的中位数得分较低，但在儿童PedsQL中无差异（p = 0.3）。
代理IXTQ比代理PedsQL更常检测到与间歇性外斜视相关的HRQOL降低。儿童IXTQ和儿童PedsQL中低于正常水平的分数较少。间歇性外斜视儿童在IXTQ上的平均得分低于对照组患者，但大多数个体得分仍在正常范围内。IXTQ可能对间歇性外斜视的临床评估有用。
