Tesh R B
Am J Trop Med Hyg. 1978 Jan;27(1 Pt 1):144-9. doi: 10.4269/ajtmh.1978.27.144.
The prevalence of encephalomyocarditis virus (EMC) antibodies among selected human populations in various regions of the world was determined by the plaque reduction neutralization method. Antibody rates among children ranged from 1.0 to 33.9%, while those among adults varied from 3.2 to 50.6%. No differences between sexes were found in the frequency of EMC infection. The pattern of age-specific antibody rates observed among the study populations suggests that EMC infection occurs primarily during childhood. There appeared to be no association between the presence of EMC antibodies and potential exposure to rats. Sera from diabetic, suspected encephalitis, and myocarditis patients were also examined for EMC neutralizing antibodies. The prevalence of antibodies among these groups was not significantly different from that of control populations in the same geographic regions. No association was demonstrated between EMC infection and these three diseases. The results of this study indicate that EMC infection in man is fairly common but that most human cases are probably asymptomatic and/or unrecognized.
采用蚀斑减少中和法测定了世界不同地区特定人群中脑心肌炎病毒（EMC）抗体的流行情况。儿童中的抗体率在1.0%至33.9%之间，而成人中的抗体率则在3.2%至50.6%之间。在EMC感染频率方面未发现性别差异。研究人群中观察到的年龄特异性抗体率模式表明，EMC感染主要发生在儿童期。EMC抗体的存在与潜在的大鼠接触之间似乎没有关联。还对糖尿病患者、疑似脑炎患者和心肌炎患者的血清进行了EMC中和抗体检测。这些组中抗体的流行率与同一地理区域的对照人群相比没有显著差异。未证明EMC感染与这三种疾病之间存在关联。本研究结果表明，人类中的EMC感染相当普遍，但大多数人类病例可能无症状和/或未被识别。
