Associate Professor, Saint Louis University Department of Neurology and Psychiatry, 1438 S Grand Blvd, St. Louis, MO 63104, USA.
Behav Sci Law. 2010 Mar-Apr;28(2):148-73. doi: 10.1002/bsl.923.
Behavioral geneticists are increasingly using the tools of molecular genetics to extend upon discoveries from twin, family, and adoption studies concerning the heritability of antisocial spectrum disorders and psychopathy. While there is a substantial body of research concerning antisocial spectrum disorders in the behavioral genetics literature, only a few studies could be located using the phenotype of psychopathy. In this report we summarize some of the recent molecular genetics work concerning antisocial spectrum disorders and psychopathy, with a focus on genes involved in the serotonergic and dopaminergic pathways, while also mentioning some of the novel genetic factors being considered. Monoamine oxidase (MAOA) and the serotonin transporter (5HTT) are reviewed at length, as these genes have received significant scientific attention in recent years and are sites of high biological plausibility in antisocial spectrum disorders and psychopathy.
行为遗传学家越来越多地使用分子遗传学工具，在对反社会谱系障碍和精神病态的遗传性进行双胞胎、家庭和收养研究的发现的基础上进行拓展。虽然行为遗传学文献中有大量关于反社会谱系障碍的研究，但使用精神病态的表型只能找到少数几项研究。在本报告中，我们总结了一些关于反社会谱系障碍和精神病态的最新分子遗传学研究，重点介绍了涉及 5-羟色胺能和多巴胺能途径的基因，同时也提到了一些正在考虑的新的遗传因素。单胺氧化酶 (MAOA) 和 5-羟色胺转运体 (5HTT) 进行了详细的回顾，因为这些基因近年来受到了科学界的高度关注，并且是反社会谱系障碍和精神病态中具有高度生物学可能性的位点。
