Huye Leslie E, Dotti Gianpietro
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston 77030, United States.
Discov Med. 2010 Apr;9(47):297-303.
Adoptive transfer of T cells can enhance immune-mediated elimination of tumor cells and provides a specific, non-toxic cancer therapy. This approach has been effective in treating some hematologic and solid malignancies. In addition, the ability to genetically modify T cells to enhance their activity and persistence as well as overcome tumor immune evasion mechanisms has the potential to increase the success of these therapies in a wide range of tumors. In this review we discuss methods for gene transfer and specific modifications that have been made to T cells.
过继性转移T细胞可增强免疫介导的肿瘤细胞清除，并提供一种特异性、无毒的癌症治疗方法。这种方法在治疗某些血液系统恶性肿瘤和实体瘤方面已取得成效。此外，通过基因改造T细胞来增强其活性和持久性以及克服肿瘤免疫逃逸机制，有可能提高这些疗法在多种肿瘤中的成功率。在本综述中，我们讨论了T细胞基因转移方法和已进行的特异性改造。
