金（I）催化的串联转化：一种合成吡咯并/吡啶并[2,1-a][1,3]苯并恶嗪酮和吡咯并/吡啶并[2,1-a]喹唑啉酮的简单方法。
Gold(I)-catalyzed tandem transformation: a simple approach for the synthesis of pyrrolo/pyrido[2,1-a][1,3]benzoxazinones and pyrrolo/pyrido[2,1-a]quinazolinones.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
出版信息
J Org Chem. 2010 May 21;75(10):3274-82. doi: 10.1021/jo100228u.
PMID:20426401
Abstract
We have developed a simple method for the synthesis of pyrrolo/pyrido[2,1-a][1,3]benzoxazinones and pyrrolo/pyrido[2,1-a]quinazolinones from 2-amino benzoic acids and 2-amino benzamides via a gold(I)-catalyzed tandem coupling/cyclization process. The tricyclic or polycyclic molecular architectures were constructed in one pot with the formation of three new bonds.
摘要
我们开发了一种从 2-氨基苯甲酸和 2-氨基苯甲酰胺通过金（I）催化的串联偶联/环化过程合成吡咯并/吡啶并[2,1-a][1,3]苯并恶嗪酮和吡咯并/吡啶并[2,1-a]喹唑啉酮的简单方法。三环或多环分子架构在一锅反应中构建，形成三个新键。
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