有机催化 1,3-二羰基茚满化合物与硝代苯乙烯的迈克尔加成反应。

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China.

Molecules. 2010 Apr 12;15(4):2551-63. doi: 10.3390/molecules15042551.

To map out the efficient organocatalyst requirements in the Michael addition of 1,3-dicarbonyl indane compounds to nitrostyrenes, a dozen different amino organocatalysts containing a p-toluenesulfonyl group (Ts) have been evaluated; excellent enantio-selectivities (up to er 92:8) were obtained with a primary amine-based Ts-DPEN catalyst and a plausible catalytic reaction mechanism was proposed on the basis of the experimental results.

为了绘制出 1,3-二羰基茚烷化合物与硝基亚乙烯基迈克尔加成反应中高效有机催化剂的要求，评估了十几个含有对甲苯磺酰基（Ts）的不同氨基有机催化剂；使用基于伯胺的 Ts-DPEN 催化剂获得了极好的对映选择性（高达 er 92:8），并根据实验结果提出了合理的催化反应机理。