作为对去甲肾上腺素的反应，心肌核糖核酸代谢主要方面的改变。聚腺苷酸聚合酶和核糖核酸聚合酶的行为、组蛋白的乙酰化以及多胺的合成速率。
Modifications of major aspects of myocardial ribonucleic acid metabolism as a response to noradrenaline. Behaviour of polyadenylate polymerase and ribonucleic acid polymerase, acetylation of histones and rate of synthesis of polyamines.
作者信息
Casti A, Corti A, Reali N, Mezzetti G, Orlandini G
出版信息
Biochem J. 1977 Dec 15;168(3):333-40. doi: 10.1042/bj1680333.
Abstract
Noradrenaline added to perfused rabbit heart previously perfused with labelled precursors causes, after 2.5 and 5.0 min, a general increase of specific radioactivity or RNA in subcellular fractions, but no augmentation of acetylation of F2a2 and F2a1 histone fractions and no stimulation of DNA-dependent RNA polymerase activities. Synthesis of spermidine and spermine is enhanced at 10.0 min of treatment, when there is also a fall in specific radioactivity of RNA. The cytoplasmic Mn2+-stimulated polyadenylate polymerase activity is strongly enhanced 30s to 2.5 min after injection of noradrenaline or of dibutyryl cyclic AMP. Both the cyclic nucleotide and noradrenaline have no influence in vitro on the polyadenylate polymerase reaction.
摘要
向预先用标记前体灌注的家兔心脏灌注去甲肾上腺素后，在2.5分钟和5.0分钟时，亚细胞组分中RNA的比放射性普遍增加，但F2a2和F2a1组蛋白组分的乙酰化没有增强，且DNA依赖性RNA聚合酶活性未受刺激。在处理10.0分钟时，亚精胺和精胺的合成增强，此时RNA的比放射性也下降。注射去甲肾上腺素或二丁酰环磷酸腺苷后30秒至2.5分钟，细胞质中锰离子刺激的聚腺苷酸聚合酶活性强烈增强。环核苷酸和去甲肾上腺素在体外对聚腺苷酸聚合酶反应均无影响。
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