一种二磷酸腺苷的砷类似物。
An arsenical analogue of adenosine diphosphate.
作者信息
Webster D, Sparkes M J, Dixon H B
出版信息
Biochem J. 1978 Jan 1;169(1):239-44. doi: 10.1042/bj1690239.
Abstract
An analogue of ADP was made in which the terminal phosphono-oxy group, -O-PO(OH)2, has been replaced by the arsonomethyl group, -CH2-AsO(OH)2. This compound cannot form a stable analogue of ATP because anhydrides of arsonic acids are rapidly hydrolysed, so that any enzyme that phosphorylates ADP and accepts this analogue as a substrate should release orthophosphate in its presence. The analogue proves to be a poor substrate for 3-phosphoglycerate kinase (V/Km is diminished by a factor of 10(2)-10(3)) and a very poor substrate for pyruvate kinase (V/Km is diminished by a factor of 10(5)-10(6)). No substrate action was detected with adenyl kinase and creatine kinase.
摘要
制备了一种ADP类似物，其中末端膦酰氧基（-O-PO(OH)2）被胂甲基（-CH2-AsO(OH)2）取代。该化合物不能形成稳定的ATP类似物，因为胂酸酐会迅速水解，因此任何使ADP磷酸化并将此类似物作为底物接受的酶，在其存在下都会释放出正磷酸盐。事实证明，该类似物是3-磷酸甘油酸激酶的不良底物（V/Km降低了10²-10³倍），也是丙酮酸激酶的极不良底物（V/Km降低了10⁵-10⁶倍）。用腺苷酸激酶和肌酸激酶未检测到底物作用。
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