Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
S Afr Med J. 2010 Jan;100(1):58-64.
To determine whether treatment of trichomoniasis increases the risk of prematurity.
Sub-analysis of a randomised trial.
We analysed data from HPTN trial of antenatal and intrapartum antibiotics to reduce chorioamnionitis-related perinatal HIV transmission.
Pregnant women from four sites in Africa.
Gestational age at the time of delivery or mean birth weight.
Of 2,428 women-infant pairs included, 428 (18%) had trichomoniasis at enrolment. There were no differences in infant age or birth weight between women with or without trichomoniasis. By randomisation group, there were no differences in gestational age at birth or birth weight. Of the 428 women diagnosed with trichomoniasis, 365 (83%) received antibiotics and 63 (15%) did not. In analysis of actual use of antibiotics, women with trichomoniasis who received no treatment were more likely to deliver a preterm infant when the symphysis-fundal height was used to estimate gestational age (36% v. 23%; p=0.03), but not when the Ballard score was used (16% v. 21%; p=0.41). There were no differences in mean birth weight between groups.
In pregnant women in sub-Saharan Africa, most of whom were HIV-infected, neither trichomoniasis nor its treatment appears to influence the risk of preterm birth or a low-birth-weight infant.
确定治疗滴虫病是否会增加早产的风险。
一项随机试验的亚分析。
我们分析了 HPTN 产前和产时抗生素试验的数据，以减少与绒毛膜羊膜炎相关的围产期 HIV 传播。
来自非洲四个地点的孕妇。
分娩时的胎龄或平均出生体重。
在纳入的 2428 对母婴中，428 例（18%）在入组时患有滴虫病。有滴虫病和无滴虫病的妇女的婴儿年龄或出生体重无差异。按随机分组，出生时的胎龄或出生体重无差异。在诊断为滴虫病的 428 名妇女中，365 名（83%）接受了抗生素治疗，63 名（15%）未接受治疗。在实际使用抗生素的分析中，未接受治疗的滴虫病妇女，当使用耻骨联合-宫底高度估计胎龄时，更有可能分娩早产儿（36%比 23%；p=0.03），但当使用 Ballard 评分时则不然（16%比 21%；p=0.41）。两组间的平均出生体重无差异。
在撒哈拉以南非洲的孕妇中，大多数孕妇感染了 HIV，滴虫病及其治疗似乎都不会影响早产或低出生体重儿的风险。
