Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
BJOG. 2021 Nov;128(12):1907-1915. doi: 10.1111/1471-0528.16774. Epub 2021 Jun 27.
Trichomoniasis commonly affects women of childbearing age and has been linked to several adverse birth outcomes.
To elucidate the association between trichomoniasis in pregnant women and adverse birth outcomes, including preterm delivery, prelabour rupture of membranes and low birthweight.
MEDLINE, EMBASE and ClinicalTrials.gov were systematically searched in December 2020 without time or language restrictions.
Original research studies were included if they assessed at least one of the specified adverse birth outcomes in pregnant women with laboratory-diagnosed trichomoniasis.
Estimates from included articles were either extracted or calculated and then pooled to produce a combined estimate of the association of trichomoniasis with each adverse birth outcome using the random effects model. Heterogeneity was assessed using the I statistic and Cochran's Q test.
Literature search produced 1658 publications after removal of duplicates (n = 770), with five additional publications identified by hand search. After screening titles and abstracts for relevance, full text of 84 studies was reviewed and 19 met inclusion criteria for meta-analysis. Significant associations were found between trichomoniasis and preterm delivery (OR 1.27; 95% CI 1.08-1.50), prelabour rupture of membranes (OR 1.87; 95% CI 1.53-2.29) and low birthweight (OR 2.12; 95% CI 1.15-3.91).
Trichomoniasis in pregnant women is associated with preterm delivery, prelabour rupture of membranes and low birthweight. Rigorous studies are needed to determine the impact of universal trichomoniasis screening and treatment during pregnancy on reducing perinatal morbidity.
This systematic review and meta-analysis found that in the setting of pregnancy, trichomoniasis is significantly associated with multiple adverse birth outcomes, including preterm delivery, low birthweight, and prelabour rupture of membranes.
滴虫病常影响育龄妇女，与多种不良分娩结局有关。
阐明孕妇滴虫病与不良分娩结局（包括早产、胎膜早破和低出生体重）之间的关系。
2020 年 12 月，系统检索了 MEDLINE、EMBASE 和 ClinicalTrials.gov，未设置时间和语言限制。
如果研究评估了实验室诊断为滴虫病的孕妇中至少一种指定的不良分娩结局，则纳入原始研究。
提取或计算纳入文章的估计值，然后使用随机效应模型汇总滴虫病与每种不良分娩结局关联的综合估计值。使用 I 统计量和 Cochran's Q 检验评估异质性。
去除重复项后，文献搜索产生了 1658 篇出版物（n=770），通过手工搜索又发现了另外 5 篇出版物。经过标题和摘要相关性的筛选，对 84 项研究的全文进行了审查，其中 19 项符合荟萃分析的纳入标准。结果发现，滴虫病与早产（OR 1.27；95%CI 1.08-1.50）、胎膜早破（OR 1.87；95%CI 1.53-2.29）和低出生体重（OR 2.12；95%CI 1.15-3.91）显著相关。
孕妇滴虫病与早产、胎膜早破和低出生体重有关。需要严格的研究来确定在妊娠期间进行普遍的滴虫病筛查和治疗对降低围产期发病率的影响。
本系统评价和荟萃分析发现，在妊娠环境中，滴虫病与多种不良分娩结局显著相关，包括早产、低出生体重和胎膜早破。
