Schroer T A, Sheetz M P
Department of Cell Biology and Physiology, Washington University Medical School, St. Louis, Missouri 63110.
Annu Rev Physiol. 1991;53:629-52. doi: 10.1146/annurev.ph.53.030191.003213.
Microtubule-dependent transport is necessary for the intracellular functions of mitosis and axonal transport. In addition, a variety of microtubule-based vesicle movements occur in all cells. Recent studies indicate that the depolymerization of microtubules results in significant inhibition of the recycling of the ER membrane from the ER-Golgi transition compartment and inhibition of the maturation of endosomes. Other membrane traffic events are inhibited by microtubule depolymerization, but in most cases alternate pathways can accomplish the function in question. With a more in-depth understanding of these alternate pathways and improved tools for inhibiting motor function without affecting cytoplasmic viscosity, we should be able to determine more precisely the roles of motor-dependent vesicle transport.
微管依赖运输对于有丝分裂和轴突运输的细胞内功能是必需的。此外，各种基于微管的囊泡运动在所有细胞中都会发生。最近的研究表明，微管解聚会导致内质网-高尔基体过渡区室中内质网膜回收的显著抑制以及内体成熟的抑制。其他膜运输事件也会受到微管解聚的抑制，但在大多数情况下，替代途径可以完成相关功能。随着对这些替代途径的更深入理解以及用于在不影响细胞质粘度的情况下抑制运动功能的改进工具的出现，我们应该能够更精确地确定依赖运动的囊泡运输的作用。
