关于GPCR领域不断扩展的术语：受体嵌合体和受体异聚体的含义。
On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.
作者信息
Agnati Luigi F, Guidolin Diego, Vilardaga Jean Pierre, Ciruela Francisco, Fuxe Kjell
机构信息
IRCCS San Camillo, Lido Venezia, Italy.
出版信息
J Recept Signal Transduct Res. 2010 Oct;30(5):287-303. doi: 10.3109/10799891003786226.
Abstract
The oligomerization of G protein-coupled receptors (GPCRs) is a fact that deserves further attention as increases both the complexity and diversity of the receptor-mediated signal transduction, thus enriching the cell signaling. Consequently, in the present review we tackle among others the problems concerning the terminology used to describe aspects surrounding the GPCRs oligomerization phenomenon. Therefore, the theoretical implications of the GPCR oligomerization will be briefly discussed together with possible implications of this phenomenon especially for new strategies in drug development.
摘要
G蛋白偶联受体（GPCRs）的寡聚化是一个值得进一步关注的事实，因为它增加了受体介导的信号转导的复杂性和多样性，从而丰富了细胞信号传导。因此，在本综述中，我们尤其探讨了与描述GPCRs寡聚化现象相关方面所用术语有关的问题。因此，将简要讨论GPCR寡聚化的理论意义以及这一现象的可能影响，特别是对药物开发新策略的影响。
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