Athanasou N A, Quinn J
University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital, Headington.
Ann Rheum Dis. 1991 May;50(5):311-5. doi: 10.1136/ard.50.5.311.
The antigenic phenotype of human synovial lining cells in normal and hyperplastic synovium intima was determined with a panel of monoclonal antibodies directed against a large number of well defined myeloid (macrophage/granulocyte associated) antigens. Synovial lining cells express numerous macrophage associated antigens, including CD11b (CR3), CD13, CD14, CD16 (FcRIII), CD18, CD32 (FcRII), CD45 (leucocyte common antigen), CD54 (ICAM-1), CD64 (FcRI), CD68, and CD71 (transferrin receptor). Few synovial lining cells expressed CD11a (LFA-1) and CD11c (p150,95). Subintimal macrophages expressed all the macrophage associated antigens which were present on synovial lining cells and, in addition, expressed CD15a, CD25 (interleukin-2 receptor), CD34, and CD35 (C3b receptor), none of which was present on synovial lining cells. Synovial lining cell expression of a wide range of macrophage antigens argues in favour of their marrow origin and membership of the mononuclear phagocyte system.
利用一组针对大量明确的髓系（巨噬细胞/粒细胞相关）抗原的单克隆抗体，确定了正常和增生性滑膜内膜中人类滑膜衬里细胞的抗原表型。滑膜衬里细胞表达多种巨噬细胞相关抗原，包括CD11b（CR3）、CD13、CD14、CD16（FcRIII）、CD18、CD32（FcRII）、CD45（白细胞共同抗原）、CD54（ICAM-1）、CD64（FcRI）、CD68和CD71（转铁蛋白受体）。少数滑膜衬里细胞表达CD11a（LFA-1）和CD11c（p150,95）。内膜下巨噬细胞表达滑膜衬里细胞上存在的所有巨噬细胞相关抗原，此外，还表达CD15a、CD25（白细胞介素-2受体）、CD34和CD35（C3b受体），这些抗原在滑膜衬里细胞上均不存在。滑膜衬里细胞表达多种巨噬细胞抗原，这支持了它们的骨髓起源以及单核吞噬细胞系统成员身份。
