Tian Hai-Feng, Chen Bing, Wen Jian-Fan
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan Province 650223, China.
Infect Disord Drug Targets. 2010 Aug;10(4):295-302. doi: 10.2174/187152610791591629.
Giardiasis is a worldwide parasitic disease caused by the protozoan Giardia lamblia in humans and other animals, especially live stocks. Here, we briefly review the current state of therapeutic availability for giardiasis, including chemical drugs and vaccines, and the dilemma in the prevention and treatment of this disease, including the emergence of drug resistance and the shortage of vaccine (especially for humans). Future efforts and progress in controlling giardiasis are expected in three aspects: clarification of the drug resistance mechanisms, development of efficient vaccines, and identification of more targets for new drugs and vaccines.
贾第虫病是一种由原生动物蓝氏贾第鞭毛虫引起的全球性寄生虫病，可感染人类和其他动物，尤其是家畜。在此，我们简要回顾一下贾第虫病目前的治疗方法，包括化学药物和疫苗，以及该疾病在预防和治疗方面所面临的困境，包括耐药性的出现和疫苗短缺（尤其是针对人类的疫苗）。预计在控制贾第虫病方面未来将在三个方面取得进展：阐明耐药机制、开发高效疫苗以及确定更多新药和疫苗的靶点。
