Department of Psychiatry, Christian Medical College and Hospital, Vellore, Tamilnadu 632004, India.
Gen Hosp Psychiatry. 2010 May-Jun;32(3):341.e11-3. doi: 10.1016/j.genhosppsych.2009.07.006. Epub 2009 Aug 27.
Hormonal side effects of antidepressants are infrequent, and galactorrhea is seldom mentioned among tricyclic antidepressant (TCA) and selective serotonin reuptake inhibitor (SSRI)-related side effects. Antidepressants can directly stimulate postsynaptic 5-HT receptors in the hypothalamus or indirectly inhibit the tuberoinfundibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. We describe a case of euprolactinemic galactorrhea in a postmenopausal woman, induced by imipramine and escitalopram. This report highlights the presence of unidentified novel mechanisms of antidepressant-induced galactorrhea and other possible contributors.
抗抑郁药的激素副作用并不常见，在三环类抗抑郁药（TCA）和选择性 5-羟色胺再摄取抑制剂（SSRI）相关的副作用中，很少提到泌乳。抗抑郁药可以直接刺激下丘脑的 5-HT 后突触受体，或通过 5-HT 间接抑制结节漏斗多巴胺能神经元，这可能会增加催乳素水平，进而导致泌乳。我们描述了一例绝经后妇女因使用丙咪嗪和依地普仑引起的高催乳素血症性泌乳。本报告强调了抗抑郁药引起泌乳的未知新机制及其他可能的因素。
