一例由艾司西酞普兰引起的催乳素正常性溢乳症病例。
A case with euprolactinemic galactorrhea induced by escitalopram.
作者信息
Gulsun Murat, Algul Ayhan, Semiz Umit Basar, Ates Mehmet Alpay, Doruk Ali, Ebrinc Servet, Basoglu Cengiz, Cetin Mesut
机构信息
Isparta Military Hospital, Psychiatry Service, Turkey.
出版信息
Int J Psychiatry Med. 2007;37(3):275-8. doi: 10.2190/PM.37.3.d.
Endocrine and reproductive side effects of serotonergic antidepressants are uncommon and galactorrhea is only rarely mentioned among SSRI-related side effects. Perhaps through suppression of dopamine neurotransmission releasing prolactin from tonic inhibitor control of dopamine, serotonin-enhancing antidepressants may result in a rise in prolactin levels. However, we here describe a case of euprolactinemic galactorrhea induced by the SSRI escitalopram and discuss potential mechanisms of action.
血清素能抗抑郁药的内分泌和生殖副作用并不常见，在与选择性5-羟色胺再摄取抑制剂（SSRI）相关的副作用中，溢乳现象只是很少被提及。血清素增强型抗抑郁药可能通过抑制多巴胺神经传递，使催乳素从多巴胺的紧张性抑制控制中释放出来，从而导致催乳素水平升高。然而，我们在此描述了一例由SSRI艾司西酞普兰诱发的正常催乳素血症性溢乳病例，并探讨了其潜在的作用机制。
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