Koch Horst J, Zellmer Heike
Department of Psychiatry and Psychotherapy, HELIOS Clinic Aue, D-08280 Aue, Germany.
Case Rep Med. 2011;2011:191735. doi: 10.1155/2011/191735. Epub 2011 Aug 15.
We report the case of a 25-year-old women suffering from major depression who was treated with citalopram for several weeks with doses between 20 mg and 60 mg. She gradually developed marked mydriasis within 2 months after treatment and subsequently neuritis nervi optici. Moreover, abrupt galactorrhea occurred after 2 months of treatment. All neuro-ophthalmological, neurophysiological, clinical laboratory, and neuroradiological diagnostic efforts did not reveal an underlying organic pathophysiology. The ocular symptoms disappeared rapidly after the discontinuation of citalopram and pulse therapy with methyl-prednisolone. However, galactorrhea persisted for a few weeks necessitating treatment with bromocriptine.
我们报告了一例25岁患有重度抑郁症的女性病例,她接受了数周的西酞普兰治疗,剂量在20毫克至60毫克之间。治疗后2个月内,她逐渐出现明显的瞳孔散大,随后发生视神经炎。此外,治疗2个月后突然出现溢乳。所有神经眼科、神经生理学、临床实验室和神经放射学诊断检查均未发现潜在的器质性病理生理学原因。停用西酞普兰并给予甲基泼尼松龙脉冲治疗后,眼部症状迅速消失。然而,溢乳持续了几周,需要用溴隐亭治疗。