Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA.
Vaccine. 2010 Jun 17;28(28):4478-86. doi: 10.1016/j.vaccine.2010.04.039. Epub 2010 Apr 29.
Immunization with L1 as pentavalent capsomeres or virus-like particles (VLPs) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (HPV) type from which the vaccine was derived. Conversely, vaccination with L2 minor capsid protein derived from multiple HPV types induces lower titer, but more broadly neutralizing and protective antibody responses. We combined the advantages of each protective antigen by immunization with titrated doses of multi-type L2 with either L1 capsomeres or VLP. We observed no significant interference between the L1 and L2 antibody response upon co-administration of L1 vaccines with multi-type L2 vaccines.
用五聚体衣壳或病毒样颗粒(VLPs)免疫产生高水平和长寿命的中和抗体,主要针对疫苗来源的人乳头瘤病毒(HPV)类型。相反,用来自多种 HPV 类型的 L2 次要衣壳蛋白疫苗接种会诱导较低的滴度,但更广泛的中和和保护抗体反应。我们通过用多种类型的 L2 与 L1 衣壳或 VLPs 联合免疫,结合了每种保护性抗原的优势。我们观察到在联合施用 L1 疫苗和多型 L2 疫苗时,L1 和 L2 抗体反应之间没有明显的干扰。