Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
J Pain Symptom Manage. 2010 Jun;39(6):1025-32. doi: 10.1016/j.jpainsymman.2009.11.312.
There is abundant evidence that quality of life (QOL) is compromised in persons with multiple sclerosis (MS), but researchers have not yet examined the possible association between co-occurring symptoms and QOL in this population.
The objective of this study was to examine the symptom cluster of fatigue, pain, depression, and perceived cognitive complaints and its association with QOL in individuals with MS.
The sample included 133 individuals with a definite diagnosis of MS who completed a battery of self-report measures as part of a cross-sectional study of symptoms and physical activity. The battery included the Fatigue Severity Scale, the Center for Epidemiological Studies-Depression Scale, the short form of the McGill Pain Questionnaire, the Perceived Deficits Questionnaire, and the Multiple Sclerosis Impact Scale.
Results indicated that 1) there were moderate bivariate correlations between fatigue, depression, pain, and perceived cognitive complaint scores; 2) the correlations between scores from the pairs of symptoms were attenuated when expressed as partial correlations controlling for the covariance of the remaining pair of symptoms; 3) exploratory and confirmatory factor analyses supported a single-factor model for the associations among fatigue, depression, pain, and perceived cognitive complaint scores; 4) cluster analysis identified three subgroups differing in experiences of fatigue, depression, pain, and perceived cognitive complaints; and 5) analysis of variance indicated a possible dose-response relationship between worsening symptoms and psychological and physical domains of QOL.
Such findings provide emerging support for a dose-response relationship between worsening symptoms of fatigue, pain, depression, and perceived cognitive complaints and QOL in persons with MS.
有大量证据表明，多发性硬化症（MS）患者的生活质量（QOL）受损，但研究人员尚未研究该人群中同时存在的症状与 QOL 之间的可能关联。
本研究旨在研究疲劳、疼痛、抑郁和感知认知主诉的症状群及其与 MS 个体 QOL 的相关性。
该样本包括 133 名确诊为 MS 的个体，他们完成了一系列自我报告措施，作为对症状和身体活动的横断面研究的一部分。该电池包括疲劳严重程度量表、流行病学研究中心抑郁量表、麦吉尔疼痛问卷简表、感知缺陷问卷和多发性硬化症影响量表。
结果表明：1）疲劳、抑郁、疼痛和感知认知主诉得分之间存在中度双变量相关性；2）当以控制剩余对症状协方差的偏相关形式表示时，症状得分之间的相关性减弱；3）探索性和验证性因子分析支持疲劳、抑郁、疼痛和感知认知主诉得分之间关联的单因素模型；4）聚类分析确定了在疲劳、抑郁、疼痛和感知认知主诉方面存在三种体验不同的亚组；5）方差分析表明，症状恶化与 QOL 的心理和身体领域之间可能存在剂量反应关系。
这些发现为 MS 患者疲劳、疼痛、抑郁和感知认知主诉症状恶化与 QOL 之间的剂量反应关系提供了初步支持。
