Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Colloids Surf B Biointerfaces. 2010 Aug 1;79(1):198-204. doi: 10.1016/j.colsurfb.2010.03.047. Epub 2010 Apr 8.
We developed a newly developed macromolecular assembly, a trilayered polymeric micelle, which can encapsulate hydrophilic compounds. The optimal condition for preparing a stable w/o emulsion was determined by the evaluation of several factors such as the composition of phase-forming organic solvents and the concentration of an emulsion stabilizer. Then, the trilayered polymeric micelle was prepared under the optimal condition for preparing the stable w/o emulsion. The results of DLS, GPC, (1)H NMR, and fluorescence microscopy suggested that the trilayered polymeric micelle was successfully prepared. It was also clarified that the micelle can encapsulate the model hydrophilic compound, FITC-dextran, into the core of the micelle. The micelle can be expected to incorporate/release compounds effectively by means of the possible optimization of the entanglement of PLA segments forming the shell layer of the micelle. These features strongly suggest that the micelle can have a variety of future applications, especially in medical fields.
我们开发了一种新的大分子组装体，即三层聚合物胶束，可以包裹亲水性化合物。通过评估形成有机相的溶剂组成和乳化稳定剂的浓度等几个因素，确定了制备稳定的油包水乳液的最佳条件。然后，在制备稳定的油包水乳液的最佳条件下制备了三层聚合物胶束。DLS、GPC、（1）H NMR 和荧光显微镜的结果表明成功制备了三层聚合物胶束。还证实了该胶束可以将模型亲水性化合物 FITC-葡聚糖包裹在胶束的核心内。通过可能优化形成胶束壳层的 PLA 段的缠结，胶束可以预期有效地包封/释放化合物。这些特点强烈表明，该胶束具有多种未来的应用，特别是在医学领域。
