Janifer J, Geethalakshmi S, Satyavani K, Viswanathan V
Department of Microbiology, M.V. Hospital for Diabetes and Diabetes Research Centre, [WHO Collaborating Centre for Research Education and Training in Diabetes], Chennai - 600 013, India.
Indian J Nephrol. 2009 Jul;19(3):107-11. doi: 10.4103/0971-4065.57107.
This study was done to determine the prevalence of lower urinary tract infection (UTI), the causative pathogens, their antimicrobial pattern, and the recurrence of infection in type 2 diabetic subjects. A total of 1157 (M: F 428: 729) type 2 diabetic subjects were selected for this study. Midstream urine specimens were collected and the culture tests were done by a quantitative method whereas antimicrobial sensitivity was determined by using the Kirby-Bauer method. A significant colony count was seen in 495 (42.8%) subjects and an insignificant count in 350 (30.3%) subjects; there were a few cases of recurrent UTI. Women (47.9%) had a significantly higher prevalence of UTI than men (34.1%) (chi(2) = 20.3, P < 0.0001). Except for BMI, UTI was significantly associated with age, duration of diabetes, and poor glycemic control in both sexes. About 533 pathogens of gram positive and gram negative bacilli were isolated from 495 subjects in this study. Escherichea coli (E. coli) was the most commonly found organism. Gram negative pathogens were found to be highly sensitive to sulbactum / cefoperazone and piperacillin / tazobactum. The prevalence of UTI was significantly higher in women than men with E. coli being the major isolated pathogen. Gram negative pathogens were highly sensitive to sulbactum / cefoperazone and piperacillin / tazobactum.
本研究旨在确定2型糖尿病患者下尿路感染（UTI）的患病率、致病病原体、它们的抗菌模式以及感染的复发情况。本研究共选取了1157名（男：女为428:729）2型糖尿病患者。收集中段尿标本，并采用定量方法进行培养试验，而抗菌敏感性则通过Kirby-Bauer方法测定。495名（42.8%）受试者菌落计数显著，350名（30.3%）受试者菌落计数不显著；有少数复发性UTI病例。女性UTI患病率（47.9%）显著高于男性（34.1%）（χ² = 20.3，P < 0.0001）。除体重指数外，UTI在男女两性中均与年龄、糖尿病病程及血糖控制不佳显著相关。本研究从495名受试者中分离出约533株革兰氏阳性和革兰氏阴性杆菌病原体。大肠埃希菌（E. coli）是最常见的病原体。革兰氏阴性病原体对舒巴坦/头孢哌酮和哌拉西林/他唑巴坦高度敏感。女性UTI患病率显著高于男性，大肠埃希菌是主要分离出的病原体。革兰氏阴性病原体对舒巴坦/头孢哌酮和哌拉西林/他唑巴坦高度敏感。
