一项对印度南部十年间从尿液样本中分离出的菌株的抗菌药敏模式的回顾性研究。

A retrospective study of the antimicrobial susceptibility patterns of isolated from urine samples over a decade in South India.

作者信息

Neelambike Sumana Mahadevaiah, Maheshwarappa Yogeesh D, G Kalyani, Mahale Rashmi P, G S Sowmya, Raghavendra Rao Morubagal, Shankaregowda Ranjitha, Chitaragi Vidyavathi B, R Deepashree, S R Sujatha, Murthy Neetha S, Satyasai Badveti, Vinay Kumar Vasimalli, Shettar Supreeta R

机构信息

Department of Microbiology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India.

IDepartment of General Pathology and Microbiology, Dayanand Sagar College of Dental Science, Bengaluru, India.

出版信息

Front Microbiol. 2025 Jun 17;16:1553943. doi: 10.3389/fmicb.2025.1553943. eCollection 2025.

DOI:10.3389/fmicb.2025.1553943

PMID:40600137

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12209295/

Abstract

INTRODUCTION

Urinary tract infections (UTIs) are common bacterial infections with significant health implications. This study aimed to assess the antimicrobial susceptibility (AST) patterns of isolated from urine samples over a decade (2014-2023).

METHODS

The study analyzed isolates AST pattern from urine samples at a tertiary care hospital in Mysuru (Karnataka), South India using the VITEK-2 (bioMérieux, France) database.

RESULTS

Of 73,283 urine samples, 21,362 (29.15%) showed significant bacterial growth. The most frequently isolated organism was ( = 9,211, 43.11%), followed by ( = 1,108, 5.18%) and ( = 920, 4.30%). Of the 920 isolates, 385 (41.84%) were carbapenem-resistant (CRKP). Isolation rates were higher in males ( = 229, 59.48%) than females ( = 156, 40.52%), with a statistically significant -value (<0.0001). Carbapenem resistance rose from 3.70% in 2014 to 66.13% in 2021, then declined to 38.55% in 2023. Resistance to fluoroquinolones, aminoglycosides, and cephalosporins increased, with cephalosporin resistance exceeding 85% by 2023. These trends reflect growing drug resistance among .

CONCLUSION

The study reveals a significant rise in antimicrobial resistance in Klebsiella pneumoniae, particularly to carbapenems and fluoroquinolones. Effective treatment requires antibiotic stewardship, strict infection control, and ongoing surveillance to maintain therapeutic options.

摘要

引言

尿路感染（UTIs）是常见的细菌感染，对健康有重大影响。本研究旨在评估过去十年（2014 - 2023年）从尿液样本中分离出的细菌的抗菌药敏（AST）模式。

方法

该研究使用VITEK - 2（法国生物梅里埃公司）数据库分析了印度南部迈索尔（卡纳塔克邦）一家三级护理医院尿液样本中的细菌AST模式。

结果

在73283份尿液样本中，21362份（29.15%）显示有显著细菌生长。最常分离出的病原体是肺炎克雷伯菌（n = 9211，43.11%），其次是大肠埃希菌（n = 1108，5.18%）和金黄色葡萄球菌（n = 920，4.30%）。在920株肺炎克雷伯菌分离株中，385株（41.84%）对碳青霉烯类耐药（CRKP）。男性的分离率（n = 229，59.48%）高于女性（n = 156，40.52%），P值具有统计学意义（<0.0001）。碳青霉烯类耐药率从2014年的3.70%上升到2021年的66.13%，然后在2023年降至38.55%。对氟喹诺酮类、氨基糖苷类和头孢菌素类的耐药性增加，到2023年头孢菌素类耐药率超过85%。这些趋势反映了肺炎克雷伯菌耐药性的不断增加。