Reddy M M, Grieco M H
RA Cooke Institute of Allergy, St Luke's-Roosevelt Hospital Center, New York, New York 10019.
Int J STD AIDS. 1991 Mar-Apr;2(2):128-32. doi: 10.1177/095646249100200211.
Levels of erythropoietin and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured in sera of 28 HIV-seronegative heterosexual non-intravenous drug using controls, 57 HIV-seronegative and 42 HIV-seropositive asymptomatic intravenous drug users (IVDU) and 36 HIV-seronegative and 36 HIV-seropositive homosexuals, 79 patients with lymphadenopathy, 11 patients with AIDS-related complex (ARC) and 110 patients with AIDS. Serum erythropoietin levels were significantly elevated in HIV-seronegative and HIV-seropositive asymptomatic homosexuals and in patients with lymphadenopathy, ARC and AIDS when compared to controls. However, in asymptomatic HIV-seronegative and HIV-seropositive IVDU the erythropoietin levels were not significantly different from the control group. GM-CSF mean levels in both HIV-seronegative and HIV-seropositive IVDU were elevated compared with the level in controls, whereas the mean levels in both the HIV-seronegative and HIV-seropositive homosexuals were decreased relative to the level in controls. GM-CSF levels in patients with lymphadenopathy, ARC and AIDS were not significantly different from the control value. It appears that male homosexuals have mildly increased erythropoietin levels which rise substantially with the development of ARC and AIDS, which suggests that AIDS patients have intact capacity to produce erythropoietin. In contrast, GM-CSF levels are increased in association with IVDU but are not increased in association with HIV infection including ARC or AIDS. The difference in circulating levels of erythropoietin and GM-CSF may reflect the tissue sources of erythropoietin predominantly in the kidney and GM-CSF being a product of the immunological and inflammatory systems.
在28名血清HIV阴性、非静脉吸毒的异性恋对照者、57名血清HIV阴性和42名血清HIV阳性的无症状静脉吸毒者（IVDU）、36名血清HIV阴性和36名血清HIV阳性的同性恋者、79名淋巴结病患者、11名艾滋病相关综合征（ARC）患者以及110名艾滋病患者的血清中检测了促红细胞生成素和粒细胞-巨噬细胞集落刺激因子（GM-CSF）的水平。与对照组相比，血清HIV阴性和血清HIV阳性的无症状同性恋者以及淋巴结病、ARC和艾滋病患者的血清促红细胞生成素水平显著升高。然而，无症状的血清HIV阴性和血清HIV阳性的IVDU的促红细胞生成素水平与对照组无显著差异。与对照组相比，血清HIV阴性和血清HIV阳性的IVDU的GM-CSF平均水平均升高，而血清HIV阴性和血清HIV阳性的同性恋者的平均水平相对于对照组则降低。淋巴结病、ARC和艾滋病患者的GM-CSF水平与对照值无显著差异。似乎男性同性恋者的促红细胞生成素水平略有升高，随着ARC和艾滋病的发展会大幅上升，这表明艾滋病患者具有完整的促红细胞生成素产生能力。相比之下，GM-CSF水平与IVDU相关升高，但与包括ARC或艾滋病在内的HIV感染无关。促红细胞生成素和GM-CSF循环水平的差异可能反映了促红细胞生成素主要来源于肾脏组织，而GM-CSF是免疫和炎症系统的产物。
