胃癌中 sonic hedgehog 再激活的作用。
The role of sonic hedgehog reemergence during gastric cancer.
机构信息
Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Room 1113, MSB, Cincinnati, OH 45267-0576, USA.
出版信息
Dig Dis Sci. 2010 Jun;55(6):1516-24. doi: 10.1007/s10620-010-1252-z. Epub 2010 May 1.
Abstract
Sonic Hedgehog (Shh) signaling has been extensively studied for its role in developmental biology and cancer biology. The association between Shh and cancer development in general is well established but the functional role of Shh in the development and progression of gastric cancer specifically is largely unknown. Bone marrow-derived stem cells, specifically mesenchymal stem cells (MSCs) infiltrate and engraft into the gastric mucosa in response to the chronic inflammatory environment of Helicobacter infection. In this review, MSC infiltration and changes in the cytokine and cellular profiles of later-stage chronic environments will be tied into their interactions with the Shh pathway. We will discuss how these changes shape tumorigenesis and tumor progression in the gastric mucosa. The current review focuses on the Shh signaling pathway and its role in the development of gastric cancer, specifically in response to Helicobacter pylori infection. We follow with an in-depth discussion of the regulation of the Hedgehog pathway during acute and chronic gastric inflammation with a focus on signaling within the MSC compartment.
摘要
Sonic Hedgehog（Shh）信号在发育生物学和癌症生物学中的作用已经得到了广泛的研究。Shh 与癌症发展之间的关联已得到充分证实，但 Shh 在胃癌的发生和发展中的具体功能作用在很大程度上尚不清楚。骨髓来源的干细胞，特别是间充质干细胞（MSCs），会在慢性炎症环境（如幽门螺杆菌感染）的刺激下浸润并植入胃黏膜。在这篇综述中，我们将探讨 MSCs 的浸润以及晚期慢性环境中细胞因子和细胞特征的变化与 Shh 途径的相互作用。我们将讨论这些变化如何影响胃黏膜的肿瘤发生和肿瘤进展。目前的综述主要关注 Shh 信号通路及其在胃癌发展中的作用，特别是针对幽门螺杆菌感染的情况。然后，我们将深入讨论 Hedgehog 通路在急性和慢性胃炎症中的调控，重点关注 MSCs 中的信号转导。
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