幽门螺杆菌与胃癌中的白细胞介素-8。
Helicobacter pylori and interleukin-8 in gastric cancer.
机构信息
Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.
出版信息
World J Gastroenterol. 2013 Dec 7;19(45):8192-202. doi: 10.3748/wjg.v19.i45.8192.
Abstract
Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer.
摘要
幽门螺杆菌（H. pylori）是胃癌发展的主要病因。大规模的流行病学研究证实了 H. pylori 感染与癌症的发生和进展之间的强烈关联。白细胞介素-8（IL-8）在暴露于 H. pylori 的胃黏膜中过度表达。IL-8 的表达与胃癌的不良预后直接相关。IL-8 具有多种功能。除了其强大的趋化活性外，它还可以诱导癌细胞的增殖和迁移。在这篇综述中，我们重点关注与胃癌相关的 IL-8 信号转导机制的最新见解。讨论了 IL-8 与 H. pylori 的关系。我们还总结了目前针对胃癌中 IL-8 的治疗方法。
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