Department of Neurosurgery, Hope Hospital, Salford, M6 8HD, UK.
Acta Neurochir (Wien). 2010 Aug;152(8):1353-7; discussion 1357. doi: 10.1007/s00701-010-0666-x. Epub 2010 May 4.
Age is an important factor in determining prognosis following severe head injury (SHI), although mortality in patients > or =65 years is poorly reported. The aim of this study was to document mortality in patients with SHI > or =65 years.
A retrospective analysis of prospectively collected data from the TARN (Trauma Audit and Research Network) database (1996-2004) was performed. Six hundred and sixty-nine patients aged > or =65 with a GCS <9 after a head injury were identified, and mortality at 3 months was recorded.
Mortality was 71% in 65- to 70-year-old patients (n = 137) (CI, 64-79), 75% for patients aged 70-75 years (n = 147) (CI, 68-82), 85% in patients aged 75-80 years (n = 160) (79-91), and 87% for patients >80 years (n = 225) (CI, 83-91). Mortality for all patients > or =65 years with a GCS 3-5 was >80%. A better outcome was observed in patients with a GCS = 6-8 [65-70 years, 47% (CI, 30-64); 70-75 years, 56% (CI, 43-69); 75-80 years, 73% (CI, 62-85); >80 years, 79% (CI, 70-87)].
SHI-related mortality continues to increase with age. Overall, these data support a conservative approach to the severely head-injured elderly patient; however, patients presenting with a GCS = 6-8 and below the age of 75 may represent a group where more aggressive therapy may be indicated.
年龄是影响严重颅脑损伤(SHI)预后的重要因素,尽管>或= 65 岁患者的死亡率报道较少。本研究旨在记录>或= 65 岁颅脑损伤患者的死亡率。
对 TARN(创伤审核和研究网络)数据库(1996-2004 年)前瞻性收集的数据进行回顾性分析。共确定了 669 名年龄>或= 65 岁且 GCS <9 的颅脑损伤患者,记录了 3 个月时的死亡率。
65-70 岁患者(n = 137)死亡率为 71%(CI,64-79),70-75 岁患者(n = 147)死亡率为 75%(CI,68-82),75-80 岁患者(n = 160)死亡率为 85%(CI,79-91),>80 岁患者(n = 225)死亡率为 87%(CI,83-91)。所有 GCS 3-5 的>或= 65 岁患者的死亡率均>80%。GCS = 6-8 的患者预后较好[65-70 岁,47%(CI,30-64);70-75 岁,56%(CI,43-69);75-80 岁,73%(CI,62-85);>80 岁,79%(CI,70-87)]。
颅脑损伤相关死亡率随年龄增长而持续增加。总的来说,这些数据支持对老年严重颅脑损伤患者采取保守治疗;然而,GCS = 6-8 且年龄<75 岁的患者可能代表一个更适合积极治疗的群体。