Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Pharmacoepidemiol Drug Saf. 2010 May;19(5):525-8. doi: 10.1002/pds.1936.
Recent research findings suggest possible increases in risk of suicidal behaviors among patients treated with anticonvulsants. The available evidence appears to support such a risk more clearly for patients diagnosed with epilepsy rather than with primary psychiatric disorders. However, the studies involved are limited by providing associational findings that may be confounded by several uncontrolled variables. Such limitations should be considered in future research on adverse effects of anticonvulsants and other centrally acting drugs. For now, however, clinical prudence calls for routine, ongoing assessment of mood and suicidal thoughts among neurological or psychiatric patients, whether or not treated with particular drugs.
最近的研究结果表明，接受抗惊厥药物治疗的患者自杀行为的风险可能会增加。现有证据似乎更清楚地表明，这种风险在被诊断患有癫痫而不是原发性精神障碍的患者中更为明显。然而，这些研究受到限制，只能提供可能受到多种未控制变量混杂的关联发现。在未来对抗惊厥药物和其他中枢作用药物不良反应的研究中，应考虑到这些局限性。然而，就目前而言，临床谨慎要求对神经或精神科患者的情绪和自杀念头进行常规、持续评估，无论是否使用特定药物治疗。
