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癫痫:抗癫痫药物与自杀行为风险。

Epilepsy: Risk of suicidal behavior with antiepileptic drugs.

机构信息

Department of Neuroscience, Mental Health and Sensory Functions, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, Rome, Italy.

出版信息

Nat Rev Neurol. 2010 Dec;6(12):651-3. doi: 10.1038/nrneurol.2010.165.

DOI:10.1038/nrneurol.2010.165
PMID:21131913
Abstract

Antiepileptic drugs (AeDs) are receiving increasing attention for a possible association with suicidal thoughts and behaviors. Several recent studies examining this association, however, have yielded inconsistent findings, particularly in terms of the risk of suicidal behavior conferred by specific AeDs. In patients with epilepsy, heightened suicide risk is also attributable to comorbid psychiatric conditions.

摘要

抗癫痫药物(AeDs)因其可能与自杀意念和行为有关而受到越来越多的关注。然而,最近几项研究检查了这种关联,结果发现并不一致,特别是特定 AeDs 导致自杀行为的风险。在癫痫患者中,自杀风险增加也归因于合并的精神疾病。

相似文献

1
Epilepsy: Risk of suicidal behavior with antiepileptic drugs.癫痫:抗癫痫药物与自杀行为风险。
Nat Rev Neurol. 2010 Dec;6(12):651-3. doi: 10.1038/nrneurol.2010.165.
2
Epilepsy, antiepileptic drugs and suicidality.癫痫、抗癫痫药物与自杀。
Curr Opin Neurol. 2011 Apr;24(2):177-82. doi: 10.1097/WCO.0b013e328344533e.
3
Suicidality in Epilepsy: Does It Share Common Pathogenic Mechanisms with Epilepsy?癫痫相关自杀行为:与癫痫是否具有共同的发病机制?
Curr Top Behav Neurosci. 2022;55:209-250. doi: 10.1007/7854_2021_220.
4
Suicide and epilepsy: do antiepileptic drugs increase the risk?自杀与癫痫:抗癫痫药物会增加风险吗?
Expert Opin Drug Saf. 2015 Apr;14(4):553-8. doi: 10.1517/14740338.2015.1010506. Epub 2015 Feb 3.
5
Is antiepileptic drug use related to depression and suicidal ideation among patients with epilepsy?抗癫痫药物的使用与癫痫患者的抑郁和自杀意念有关吗?
Epilepsy Behav. 2010 Nov;19(3):494-500. doi: 10.1016/j.yebeh.2010.08.030. Epub 2010 Sep 28.
6
Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy.癫痫患者接受抗癫痫药物治疗后的自杀风险和自杀企图。
Seizure. 2011 May;20(4):280-4. doi: 10.1016/j.seizure.2010.12.010. Epub 2011 Jan 26.
7
Suicidality in people taking antiepileptic drugs: What is the evidence?服用抗癫痫药物人群的自杀倾向:有哪些证据?
CNS Drugs. 2009;23(4):281-92. doi: 10.2165/00023210-200923040-00002.
8
Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior.抗癫痫药物在癫痫中的应用与自我伤害或自杀行为的风险。
Neurology. 2010 Jul 27;75(4):335-40. doi: 10.1212/WNL.0b013e3181ea157e.
9
Is antiepileptic-induced suicidality a data-based class effect or an exaggeration? A comment on the literature.抗癫痫药物所致自杀倾向是基于数据的类效应还是夸大之词?对文献的评论。
Harv Rev Psychiatry. 2014 Nov-Dec;22(6):379-81. doi: 10.1097/HRP.0000000000000039.
10
Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology.抗癫痫药物与自杀倾向:国际抗癫痫联盟神经心理生物学委员会治疗策略特别工作小组的专家共识声明。
Epilepsia. 2013 Jan;54(1):199-203. doi: 10.1111/j.1528-1167.2012.03688.x. Epub 2012 Sep 20.

引用本文的文献

1
Suicide and Epilepsy.自杀与癫痫
Curr Neurol Neurosci Rep. 2022 Aug;22(8):441-450. doi: 10.1007/s11910-022-01206-6. Epub 2022 Jun 17.
2
Risk factors for suicidal tendency in people with epilepsy in China: a case-control study.中国癫痫患者自杀倾向的风险因素:一项病例对照研究。
Sci Rep. 2021 Feb 2;11(1):2742. doi: 10.1038/s41598-021-81870-9.
3
When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient.当病态大脑与绝望相遇:神经科患者自杀倾向的一些方面。

本文引用的文献

1
Suicide-related events in patients treated with antiepileptic drugs.抗癫痫药物治疗患者的自杀相关事件。
N Engl J Med. 2010 Aug 5;363(6):542-51. doi: 10.1056/NEJMoa0909801.
2
Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior.抗癫痫药物在癫痫中的应用与自我伤害或自杀行为的风险。
Neurology. 2010 Jul 27;75(4):335-40. doi: 10.1212/WNL.0b013e3181ea157e.
3
Suicide risk during anticonvulsant treatment.抗癫痫药物治疗期间的自杀风险。
CNS Neurol Disord Drug Targets. 2020;19(4):257-263. doi: 10.2174/1871527319666200611130804.
4
[Coexistent depressive and anxiety disorders in epilepsy and multiple sclerosis: a challenge to neuropsychiatric practice].[癫痫与多发性硬化症中共存的抑郁和焦虑障碍:对神经精神科实践的一项挑战]
Neuropsychiatr. 2014;28(3):142-50. doi: 10.1007/s40211-014-0105-y. Epub 2014 May 20.
Pharmacoepidemiol Drug Saf. 2010 May;19(5):525-8. doi: 10.1002/pds.1936.
4
Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death.抗癫痫药物与自杀、自杀未遂或暴力死亡的风险。
JAMA. 2010 Apr 14;303(14):1401-9. doi: 10.1001/jama.2010.410.
5
Antiepileptic drugs and risk of suicide: a nationwide study.抗癫痫药物与自杀风险:一项全国性研究。
Pharmacoepidemiol Drug Saf. 2010 May;19(5):518-24. doi: 10.1002/pds.1932.
6
Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system.新型抗癫痫药物治疗老年患者中的自杀相关行为:来自退伍军人事务部医院系统的数据。
BMC Med. 2010 Jan 11;8:4. doi: 10.1186/1741-7015-8-4.
7
Relationship between antiepileptic drugs and suicide attempts in patients with bipolar disorder.双相情感障碍患者中抗癫痫药物与自杀未遂之间的关系。
Arch Gen Psychiatry. 2009 Dec;66(12):1354-60. doi: 10.1001/archgenpsychiatry.2009.159.
8
Suicide in epilepsy: psychopathology, pathogenesis, and prevention.癫痫中的自杀:精神病理学、发病机制与预防
Epilepsy Behav. 2002 Jun;3(3):232-241. doi: 10.1016/s1525-5050(02)00006-9.