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Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels.
Arch Neurol. 2009 Oct;66(10):1225-32. doi: 10.1001/archneurol.2009.219.
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Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy.
Front Neurosci. 2009 May 1;3(1):25-33. doi: 10.3389/neuro.01.005.2009. eCollection 2009 May.
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Mechanisms of human inherited epilepsies.
Prog Neurobiol. 2009 Jan 12;87(1):41-57. doi: 10.1016/j.pneurobio.2008.09.016. Epub 2008 Oct 5.
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Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats.
Epilepsia. 2008 Oct;49(10):1686-95. doi: 10.1111/j.1528-1167.2008.01593.x. Epub 2008 Apr 7.
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Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.
J Neurosci. 2007 Nov 21;27(47):13012-21. doi: 10.1523/JNEUROSCI.3605-07.2007.
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Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy.
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17536-41. doi: 10.1073/pnas.0708440104. Epub 2007 Oct 18.
7
Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.
Neurobiol Dis. 2008 Jan;29(1):59-70. doi: 10.1016/j.nbd.2007.08.006. Epub 2007 Aug 24.
8
A polygenic heterogeneity model for common epilepsies with complex genetics.
Genes Brain Behav. 2007 Oct;6(7):593-7. doi: 10.1111/j.1601-183X.2007.00333.x. Epub 2007 Jun 7.
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The mechanism of carbamazepine aggravation of absence seizures.
J Pharmacol Exp Ther. 2006 Nov;319(2):790-8. doi: 10.1124/jpet.106.104968. Epub 2006 Aug 8.
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Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.
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