Department of Medicine 'B' and Centre for Autoimmune Diseases, Sheba Medical Centre, (Affiliated to Tel-Aviv University) Tel-Hashomer 52621, Israel.
Ann Rheum Dis. 2010 Jun;69(6):1155-7. doi: 10.1136/ard.2009.120329. Epub 2010 May 3.
Low serum vitamin D concentrations have been reported in several autoimmune disorders.
To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE).
378 patients from several European and Israeli cohorts were pooled and their disease activity was measured by two different methods: 278 patients had SLE disease activity-2000 (SLEDAI-2K) scores and 100 patients had European Consensus Lupus Activity Measurement (ECLAM) scores. In order to combine the two systems the scores were converted into standardised values (z-scores), enabling univariate summary statistics for the two variables (SLEDAI-2K and ECLAM). The commercial kit, LIAISON 25-OH vitamin D assay (310900-Diasorin) was used to measure serum concentration of 25-OH vitamin D in 378 patients with SLE.
A significant negative correlation was demonstrated between the serum concentration of vitamin D and the standardised values (z-scores) of disease activity scores as measured by the SLEDAI-2K and ECLAM scales (Pearson's correlation coefficient r=-0.12, p=0.018).
In a cohort of patients with SLE originating from Israel and Europe vitamin D serum concentrations were found to be inversely related to disease activity.
已有研究报道，在几种自身免疫性疾病中存在血清维生素 D 浓度较低的情况。
评估血清维生素 D 浓度较低是否与系统性红斑狼疮（SLE）患者的疾病活动度相关。
汇集了来自几个欧洲和以色列队列的 378 名患者，并使用两种不同的方法来测量他们的疾病活动度：278 名患者的 SLE 疾病活动度-2000（SLEDAI-2K）评分和 100 名患者的欧洲共识狼疮活动测量（ECLAM）评分。为了将两种系统结合起来，将这些评分转换为标准化值（z 分数），从而可以对两个变量（SLEDAI-2K 和 ECLAM）进行单变量汇总统计。使用商业试剂盒 LIAISON 25-OH 维生素 D 测定法（310900-Diasorin）测量了 378 名 SLE 患者的血清 25-OH 维生素 D 浓度。
血清维生素 D 浓度与 SLEDAI-2K 和 ECLAM 评分所测量的疾病活动度标准化值（z 分数）之间存在显著负相关（Pearson 相关系数 r=-0.12，p=0.018）。
在来自以色列和欧洲的 SLE 患者队列中，发现血清维生素 D 浓度与疾病活动度呈负相关。
