Cardona-Cardona Andrés F, Cerón Y Cerón Jairo A
Department of Internal Medicine, Universidad de Caldas, Manizales, Colombia.
Servicios Especiales de Salud Hospital de Caldas, Manizales, Colombia.
Lupus. 2020 Sep;29(10):1297-1304. doi: 10.1177/0961203320937783. Epub 2020 Jul 5.
Patients with systemic lupus erythematosus (SLE) frequently present low levels of vitamin D. However, studies that have evaluated its association with disease activity have generated contradictory results.
A cross-sectional study was carried out on patients diagnosed with SLE in two hospitals in Manizales, Colombia. Disease activity was evaluated by the SLE disease activity index 2000 (SLEDAI-2K) and serum concentration of 25-hydroxyvitamin D (25(OH)D) was measured by chemiluminescence. The correlation analysis was accomplished with the Spearman correlation coefficient.
The study included 51 patients. The median SLEDAI-2K score was 8 points. The mean serum level of 25(OH)D was 24.5 ng/ml. Of the participants, 37.3% had vitamin D insufficiency and 35.3% had deficiency. An inverse correlation was found between the levels of the 25(OH)D and the SLEDAI-2K score ( = -0.578, < 0.001), being greater in late-onset lupus, with absence of polyautoimmunity and in patients using glucocorticoids.
Low levels of vitamin D are frequent in SLE, presenting an inverse correlation with the disease activity. This is influenced by the use of glucocorticoids, the presence of late-onset lupus and the absence of polyautoimmunity.
系统性红斑狼疮（SLE）患者常常维生素D水平较低。然而，评估其与疾病活动度关联的研究结果相互矛盾。
对哥伦比亚马尼萨莱斯两家医院诊断为SLE的患者进行了一项横断面研究。采用系统性红斑狼疮疾病活动指数2000（SLEDAI - 2K）评估疾病活动度，通过化学发光法测量血清25 - 羟基维生素D（25(OH)D）浓度。采用Spearman相关系数进行相关性分析。
该研究纳入了51例患者。SLEDAI - 2K评分中位数为8分。血清25(OH)D平均水平为24.5 ng/ml。参与者中，37.3%存在维生素D不足，35.3%存在维生素D缺乏。发现25(OH)D水平与SLEDAI - 2K评分呈负相关（r = -0.578，P < 0.001），在晚发型狼疮、无多自身免疫性疾病以及使用糖皮质激素的患者中这种相关性更强。
SLE患者中维生素D水平低很常见，且与疾病活动度呈负相关。这受到糖皮质激素的使用、晚发型狼疮的存在以及无多自身免疫性疾病的影响。
