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依据心脏标准在死亡后进行心脏移植:对脑死亡判定标准的挑战

Transplanting hearts after death measured by cardiac criteria: the challenge to the dead donor rule.

作者信息

Veatch Robert M

机构信息

Georgetown University, Washington, DC 20057, USA.

出版信息

J Med Philos. 2010 Jun;35(3):313-29. doi: 10.1093/jmp/jhq020. Epub 2010 May 3.

DOI:10.1093/jmp/jhq020
PMID:20439354
Abstract

The current definition of death used for donation after cardiac death relies on a determination of the irreversible cessation of the cardiac function. Although this criterion can be compatible with transplantation of most organs, it is not compatible with heart transplantation since heart transplants by definition involve the resuscitation of the supposedly "irreversibly" stopped heart. Subsequently, the definition of "irreversible" has been altered so as to permit heart transplantation in some circumstances, but this is unsatisfactory. There are three available strategies for solving this "irreversibility problem": altering the definition of death so as to rely on circulatory irreversibility, rather than cardiac; defining death strictly on the basis of brain death (either whole-brain or more pragmatically some higher brain criteria); or redefining death in traditional terms and simultaneously legalizing some limited instances of medical killing to procure viable hearts. The first two strategies are the most ethically justifiable and practical.

摘要

目前用于心脏死亡后捐赠的死亡定义依赖于对心脏功能不可逆停止的判定。尽管这一标准与大多数器官移植兼容,但与心脏移植不兼容,因为从定义上讲,心脏移植涉及对假定“不可逆”停止跳动的心脏进行复苏。随后,“不可逆”的定义被修改,以便在某些情况下允许心脏移植,但这并不令人满意。解决这个“不可逆性问题”有三种可行策略:改变死亡定义,使其依赖于循环不可逆性而非心脏不可逆性;严格基于脑死亡(全脑死亡或更实际地基于某些高级脑标准)来定义死亡;或者用传统术语重新定义死亡,同时将一些有限的医疗杀戮实例合法化以获取可存活的心脏。前两种策略在伦理上最具正当性且最为实际。

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Transplanting hearts after death measured by cardiac criteria: the challenge to the dead donor rule.依据心脏标准在死亡后进行心脏移植:对脑死亡判定标准的挑战
J Med Philos. 2010 Jun;35(3):313-29. doi: 10.1093/jmp/jhq020. Epub 2010 May 3.
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引用本文的文献

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When are you dead enough to be a donor? Can any feasible protocol for the determination of death on circulatory criteria respect the dead donor rule?何时你才算死亡,可以捐献器官?任何基于循环标准判定死亡的可行方案,是否都能尊重死亡供者规则?
Theor Med Bioeth. 2019 Aug;40(4):299-319. doi: 10.1007/s11017-019-09500-0.
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How (not) to think of the 'dead-donor' rule.如何(不)看待“死亡供体”规则。
Theor Med Bioeth. 2018 Feb;39(1):1-25. doi: 10.1007/s11017-018-9432-5.
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Preservation of donor hearts using hypothermic oxygenated perfusion.使用低温氧合灌注保存供体心脏。
Ann Transplant. 2014 Aug 20;19:409-16. doi: 10.12659/AOT.890797.
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Heart donation after circulatory determination of death: ethically acceptable?
Nat Rev Cardiol. 2014 Sep;11(9):553. doi: 10.1038/nrcardio.2014.45-c1. Epub 2014 Jul 15.
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Brain-dead patients are not cadavers: the need to revise the definition of death in Muslim communities.脑死亡患者并非尸体:穆斯林社区修订死亡定义的必要性。
HEC Forum. 2013 Mar;25(1):25-45. doi: 10.1007/s10730-012-9196-7.
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Ethical issues in cardiac surgery.心脏外科手术中的伦理问题。
Future Cardiol. 2012 May;8(3):451-65. doi: 10.2217/fca.11.91.
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Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent.心循环死亡后的捐赠:呼吁在充分公开披露和完全知情同意之前暂停相关行为。
Philos Ethics Humanit Med. 2011 Dec 29;6:17. doi: 10.1186/1747-5341-6-17.
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One or two types of death? Attitudes of health professionals towards brain death and donation after circulatory death in three countries.一种还是两种死亡类型?三个国家卫生专业人员对脑死亡和循环性死亡后器官捐献的态度。
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