Lilja G, Dannaeus A, Foucard T, Graff-Lonnevig V, Johansson S G, Oman H
Sachs' Children's Hospital, Karolinska Institute, Stockholm, Sweden.
Clin Exp Allergy. 1991 Mar;21(2):195-202. doi: 10.1111/j.1365-2222.1991.tb00830.x.
The IgE levels and food-allergen-specific IgE- and IgG-antibodies (Ab) to ovalbumin (OA), ovomucoid (OVO) and beta-lactoglobulin (BLG) were determined up to 18 months of age in 163 infants born to women who were atopic. A high (HIGH group) or a low (REDUCED group) intake of hen's egg and cow's milk by the mother during the third trimester gave no significant differences in the concentrations of IgE or in IgE-Ab (OVO, BLG) and IgG-Ab (OA, OVO, BLG). Similarly, a prolongation of the abstention diet to the early lactation period did not influence the immune response. The IgG-Ab levels to all three food allergens decreased significantly (P less than 0.001) in both study groups between birth and 2 months of age, but then increased significantly (P less than 0.001) between 6 and 18 months of age. The presence in serum of IgE-Ab to OVO (greater than or equal to 0.15 PRU/ml) was associated with significantly higher IgG-Ab levels to OVO at 6 months (P less than 0.001) and at 18 months (P less than 0.05). Infants with positive skin-prick tests (SPT) to OA and OVO showed higher IgG-Ab levels at 6 and 18 months of age than did infants with negative SPT reactions to the two egg allergens. This indicates a relation between the IgE- and IgG-Ab response and it also suggests that some individuals are 'high responders' to both types of immunoglobulin isotypes while others are 'low responders'.
对163名患有特应性疾病的女性所生婴儿，测定其18个月龄前针对卵清蛋白（OA）、卵类粘蛋白（OVO）和β-乳球蛋白（BLG）的IgE水平以及食物过敏原特异性IgE和IgG抗体（Ab）。母亲在孕晚期高（高摄入组）或低（减少摄入组）摄入鸡蛋和牛奶，在IgE浓度、IgE抗体（OVO、BLG）和IgG抗体（OA、OVO、BLG）方面无显著差异。同样，将忌口饮食延长至哺乳期早期也未影响免疫反应。两个研究组中，出生至2个月龄时，针对所有三种食物过敏原的IgG抗体水平均显著下降（P<0.001），但在6至18个月龄时显著升高（P<0.001）。血清中存在针对OVO的IgE抗体（≥0.15 PRU/ml）与6个月龄（P<0.001）和18个月龄（P<0.05）时针对OVO的IgG抗体水平显著升高相关。对OA和OVO皮肤点刺试验（SPT）呈阳性的婴儿，在6个月和18个月龄时的IgG抗体水平高于对这两种鸡蛋过敏原SPT反应呈阴性的婴儿。这表明IgE和IgG抗体反应之间存在关联，也表明一些个体对两种免疫球蛋白同种型都是“高反应者”，而另一些则是“低反应者”。
