Schlumberger M, Brugieres L, Gicquel C, Travagli J P, Droz J P, Parmentier C
Institut Gustave-Roussy, Villejuif, France.
Cancer. 1991 Jun 15;67(12):2997-3000. doi: 10.1002/1097-0142(19910615)67:12<2997::aid-cncr2820671211>3.0.co;2-#.
Fourteen patients with progressive metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin (FAP). All had a large tumor burden. Six patients had a hormone-producing tumor; mitotane treatment was given to five of them during chemotherapy for its possible antihormonal effects. Treatment could be evaluated in 13 patients. The overall response rate was 23% (95% confidence interval [CI], 5% to 54%). A complete remission, which lasted for 42 months, was achieved in one patient. Partial remissions, which lasted for 6 and 11 months, were achieved in two patients. Cardiotoxicity appeared in three patients, myelotoxicity in four, and nephrotoxicity in one. This confirms that this regimen is an active combination for the treatment of metastatic adrenal cortical carcinoma.
14例进行性转移性肾上腺皮质癌患者接受了5-氟尿嘧啶（5-FU）、阿霉素和顺铂联合治疗（FAP方案）。所有患者肿瘤负荷均较大。6例患者为激素分泌型肿瘤；其中5例在化疗期间接受了米托坦治疗，因其可能具有抗激素作用。13例患者的治疗效果可进行评估。总体缓解率为23%（95%置信区间[CI]，5%至54%）。1例患者实现完全缓解，持续42个月。2例患者实现部分缓解，分别持续6个月和11个月。3例患者出现心脏毒性，4例出现骨髓毒性，1例出现肾毒性。这证实该方案是治疗转移性肾上腺皮质癌的一种有效联合方案。
