Schlumberger M, Ostronoff M, Bellaiche M, Rougier P, Droz J P, Parmentier C
Institut Gustave-Roussy, Villejuif, France.
Cancer. 1988 Apr 15;61(8):1492-4. doi: 10.1002/1097-0142(19880415)61:8<1492::aid-cncr2820610803>3.0.co;2-1.
Five patients with metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin. All patients had a nonhormone producing tumor. A large tumor burden made them unsuitable for mitotane treatment. Treatment could be evaluated in four patients. A complete remission was achieved in one patient and lasted for 38 months: this patient is still alive and free of disease. Furthermore, a minor response and a disease stabilization also were observed. Cardiotoxicity occurred in one patient and myelosuppression in another patient. This regimen appears to be an active combination for the treatment of metastatic adrenal cortical carcinoma.
五例转移性肾上腺皮质癌患者接受了氟尿嘧啶（5-FU）、阿霉素和顺铂联合治疗。所有患者的肿瘤均不产生激素。巨大的肿瘤负荷使他们不适于用米托坦治疗。四名患者的治疗效果可作评估。一名患者实现完全缓解，缓解持续38个月：该患者仍存活且无疾病。此外，还观察到一名患者有轻度缓解，另一名患者病情稳定。一名患者出现心脏毒性，另一名患者出现骨髓抑制。该治疗方案似乎是治疗转移性肾上腺皮质癌的一种有效联合方案。
