Talebi-Taher Mahshid, Kashanian Maryam, Khalili Katayoon
Antimicrobial Resistance Research Center, Infectious Diseases Department, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran.
Iran J Microbiol. 2014 Feb;6(1):37-40.
Varicella zoster virus (VZV) can cause life-threatening disease in pregnant women. The aim of this study was to identify the VZV immune status in pregnant women and also determine the validity of self-reported history for chickenpox.
Serologic testing for VZV was performed for 400 pregnant women attending prenatal care at clinics located in two teaching and referral hospitals in Tehran, Iran. The Enzyme Immunoassay method was used to assess IgG antibodies against VZV.
A total of 400 pregnant women, aged 16-43 years (median: 27 years, mean: 27.6 ± 5.9 years), were examined in which 361 (90.3%) were found to be seropositive. Sensitivity, specificity and positive and negative predictive values of patients' self reported history were 51.8%, 71.7%, 94.4% and 13.8% respectively.
Serologic screening for VZV in pregnant women seems crucial. We suggest considering the pregnant women as the target group for future immunization programs in Iran.
水痘带状疱疹病毒（VZV）可在孕妇中引发危及生命的疾病。本研究旨在确定孕妇的VZV免疫状态，并评估水痘自我报告病史的有效性。
对在伊朗德黑兰两家教学和转诊医院的诊所进行产前检查的400名孕妇进行了VZV血清学检测。采用酶免疫测定法评估抗VZV的IgG抗体。
共检查了400名年龄在16 - 43岁（中位数：27岁，平均：27.6±5.9岁）的孕妇，其中361名（90.3%）血清学检测呈阳性。患者自我报告病史的敏感性、特异性、阳性预测值和阴性预测值分别为51.8%、71.7%、94.4%和13.8%。
孕妇的VZV血清学筛查似乎至关重要。我们建议将孕妇视为伊朗未来免疫规划的目标群体。
