Allami Abbas, Mohammadi Navid
Department of Infectious Disease, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Community Medicine, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Iran J Microbiol. 2014 Dec;6(6):372-81.
To generate synthesized information on the epidemiology of VZV infection, as well as an estimation of prevalence of age-specific antibody in Iranian less than 40.
After exclusion of irrelevant and overlapping reports, 15 papers were included (from nine major cities). Studies were pooled according to the heterogeneity test results. Random effect model methods were used for meta-analysis where significant heterogeneity was observed (age 1-16years).For other age groups, fixed model were used.
Significant heterogeneity was observed in prevalence rates of all childhood age-groups. The seropositivity prevalence increased steeply from the age of 1-5 to 6-10 [from 21.9% (95% CI; 10.8-33.1) to 42.1 %(95% CI; 33.6-50.6)]. At the age of 11 15, 59.4% (95% CI; 46.1-72.8) of children showed to be infected. The rate of seropositivity was more than 87% in individuals of 40 and older.
The varicella seroeprevalence in Iran is in accordance with average tropical and temperate areas. Comparison of conducted studies during 2003 to 2011 didn't show any alteration in VZV seroprovalence in Iran.
生成关于水痘带状疱疹病毒（VZV）感染流行病学的综合信息，并估计伊朗40岁以下特定年龄抗体的流行率。
排除不相关和重叠的报告后，纳入了15篇论文（来自九个主要城市）。根据异质性检验结果对研究进行合并。对于观察到显著异质性的年龄组（1 - 16岁），采用随机效应模型方法进行荟萃分析。对于其他年龄组，使用固定模型。
在所有儿童年龄组的流行率中观察到显著异质性。血清阳性流行率从1 - 5岁到6 - 10岁急剧上升[从21.9%（95%置信区间；10.8 - 33.1）升至42.1%（95%置信区间；33.6 - 50.6）]。在11 - 15岁时，59.4%（95%置信区间；46.1 - 72.8）的儿童显示受到感染。40岁及以上个体的血清阳性率超过87%。
伊朗水痘血清流行率与热带和温带地区的平均水平一致。2003年至2011年期间进行的研究比较未显示伊朗VZV血清流行率有任何变化。
