神经生长因子抑制人浆细胞系的免疫球蛋白产生，但不抑制其增殖。
Nerve growth factor inhibits immunoglobulin production by but not proliferation of human plasma cell lines.
作者信息
Kimata H, Yoshida A, Ishioka C, Mikawa H
机构信息
Department of Pediatrics, Faculty of Medicine, Kyoto University Hospital, Japan.
出版信息
Clin Immunol Immunopathol. 1991 Jul;60(1):145-51. doi: 10.1016/0090-1229(91)90120-y.
The effects of nerve growth factor (NGF) on human plasma cells were studied. NGF inhibited immunoglobulin (Ig) production but not thymidine uptake by human plasma cell lines IM-9 and AF-10 in a dose-dependent fashion. This NGF-induced inhibition of Ig production was specific, since inhibition was blocked by anti-NGF serum but not by control serum. Interleukin (IL)-6 did not affect Ig production by IM-9 and AF-10; however, IL-6 restored NGF-induced inhibition of Ig production. NGF also inhibited Ig production (IgG, IgM, and IgA) without affecting thymidine uptake by PCA-1+ plasma cells generated in vitro. This inhibition was also blocked by anti-NGF serum but not by control serum and was restored by IL-6. These results suggest that NGF may interact with IL-6 in control of Ig production by plasma cells.
研究了神经生长因子（NGF）对人浆细胞的作用。NGF以剂量依赖的方式抑制人浆细胞系IM-9和AF-10的免疫球蛋白（Ig）产生，但不抑制其胸腺嘧啶核苷摄取。这种NGF诱导的Ig产生抑制是特异性的，因为抗NGF血清可阻断抑制作用，而对照血清则不能。白细胞介素（IL）-6不影响IM-9和AF-10的Ig产生；然而，IL-6可恢复NGF诱导的Ig产生抑制。NGF还抑制体外产生的PCA-1+浆细胞的Ig产生（IgG、IgM和IgA），而不影响其胸腺嘧啶核苷摄取。这种抑制也被抗NGF血清阻断，而不是被对照血清阻断，并被IL-6恢复。这些结果表明，NGF可能在浆细胞Ig产生的控制中与IL-6相互作用。
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