串联迈克尔加成/分子内异氰酸酯 [3 + 2] 环加成：高非对映选择性一锅法合成稠合恶唑啉。

Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolines.

机构信息

Department of Chemistry, Northeast Normal University, Changchun 130024, China.

出版信息

Chem Commun (Camb). 2010 May 21;46(19):3357-9. doi: 10.1039/c001617a. Epub 2010 Mar 25.

PMID:20442900

Abstract

A base-catalyzed tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition of ethyl isocyanoacetate and Michael acceptors with tethered carbonyl groups is described. This reaction leads to the formation of fused oxazolines in a highly diastereoselective manner under very mild conditions.

摘要

描述了一种基于碱催化的串联迈克尔加成/分子内异氰酸酯 [3 + 2] 环加成反应，其中包括乙基异氰基乙酸酯和带有桥连羰基的迈克尔受体。在非常温和的条件下，该反应以高度非对映选择性的方式生成稠合恶唑啉。