通过乙烯基亚膦酰胺的串联氮杂-维蒂希/迈克尔/异构化反应意外合成 2,4,5-三取代恶唑。
Unexpected synthesis of 2,4,5-trisubstituted oxazoles via a tandem aza-Wittig/Michael/isomerization reaction of vinyliminophosphorane.
机构信息
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, 430079, People's Republic of China.
出版信息
J Org Chem. 2012 Mar 16;77(6):2954-8. doi: 10.1021/jo202588j. Epub 2012 Feb 24.
PMID:22332823
Abstract
2,4,5-Trisubstituted oxazoles 6 were unexpectedly prepared from a tandem reaction of vinyliminophosphorane 3 with various acyl chlorides in a one-pot fashion.
摘要
2,4,5-三取代恶唑 6 可通过乙烯亚膦酰氯 3 与各种酰氯的一锅串联反应意外地制备。
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