Clermont Université, Université Blaise Pascal, Laboratoire SEESIB, BP 10448, F-63000, Clermont-Ferrand, France.
Org Biomol Chem. 2010 Jun 28;8(13):2941-55. doi: 10.1039/b923275c. Epub 2010 May 4.
Azide- and alkynyl-containing homo-beta(3)-peptides, of up to six residues in length, were synthesised in solution from aspartic acid. Their subsequent conjugation with monosaccharides bearing an azide or a terminal alkyne function was efficiently achieved by copper-mediated cycloadditions leading to two novel families of small glycoclusters. These compounds represent ideal tools to explore carbohydrate-mediated multivalent interactions.
叠氮化物和炔基含有同型β（3）-肽，长度可达六个残基，从天冬氨酸在溶液中合成。它们随后与带有叠氮化物或末端炔基功能的单糖的缀合通过铜介导的环加成反应有效地实现，导致两种新型的小糖缀合物家族。这些化合物是探索碳水化合物介导的多价相互作用的理想工具。
