European Commission-Joint Research Centre, Institute for Health and Consumer Protection, Via E. Fermi, 21027 Ispra (VA), Italy.
Expert Opin Drug Metab Toxicol. 2010 Jul;6(7):785-92. doi: 10.1517/17425255.2010.489551.
The methods and tools of computational toxicology form an essential and integrating pillar in the new paradigm of predictive toxicology, which seeks to develop more efficient and effective means of assessing chemical toxicity, while also reducing animal testing. The increasingly prominent role of computational toxicology in the implementation of European chemicals' legislation is described, along with initiatives by the European Commission's Joint Research Centre to promote the acceptance and use of computational methods. Outstanding needs and scientific challenges are also outlined. In recent years, there have been impressive scientific and technological advances in computational toxicology. However, considerable progress is still needed to increase the acceptance of computational methods, and in particular to develop a deeper and common understanding of how to apply computational toxicology in regulatory decision making.
计算毒理学的方法和工具构成了预测毒理学新模式的一个重要的、综合的支柱，该模式旨在开发更有效和高效的化学毒性评估手段，同时减少动物测试。本文描述了计算毒理学在实施欧洲化学品法规方面日益突出的作用，以及欧盟委员会联合研究中心为促进计算方法的接受和使用而采取的举措。本文还概述了突出的需求和科学挑战。近年来，计算毒理学在科学和技术方面取得了令人瞩目的进展。然而，要提高对计算方法的接受程度，特别是要深入和普遍了解如何在监管决策中应用计算毒理学，仍需要取得相当大的进展。
