Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Mol Microbiol. 2010 May;76(4):822-32. doi: 10.1111/j.1365-2958.2010.07168.x. Epub 2010 Apr 25.
Understanding the mechanisms that underlie the organization of bacterial cells has become a significant challenge in the field of bacterial cytology. Of specific interest are early macromolecular sorting events that establish cellular non-uniformity and provide chemical landmarks for later localization events. In this review, we will examine specific examples of lipids and proteins that appear to exploit differences in membrane curvature to drive their localization to particular regions of a bacterial cell. We will also discuss the physical limits of curvature-mediated localization within bacteria, and the use of modelling to infer biophysical properties of curvature-sensing macromolecules.
了解细菌细胞组织的机制已成为细菌细胞学领域的重大挑战。特别有趣的是早期的大分子分拣事件，这些事件确立了细胞的非均一性，并为后来的定位事件提供了化学标志物。在这篇综述中，我们将研究脂质和蛋白质的具体例子，这些例子似乎利用了膜曲率的差异来驱动它们在细菌细胞的特定区域定位。我们还将讨论曲率介导的定位在细菌中的物理限制，以及使用建模来推断曲率感应大分子的生物物理特性。
