Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Box 980126, 800 E. Leigh Street, Richmond, VA 23298-0126, USA.
Eur Psychiatry. 2010 Jun;25(5):300-3. doi: 10.1016/j.eurpsy.2010.01.005. Epub 2010 May 4.
This paper presents a tentative typology of genetic and environmental pathways to suicidal behavior. Ten pathways are proposed and briefly illustrated: (i) direct effects from psychiatric disorders; (ii) direct effects from personality; (iii) direct effects of early adversity; (iv) direct effects of current adversity; (v) indirect effects of genes on selection into adversity (gene-environment correlation); (vi) interactions between genetic risk and current adversity: gene-environment interaction; (vii) interactions between early and current adversity: environment-environment interaction; (viii) interactions between culture and genes; (ix) dynamic developmental pathways involving causal loops from genes to environment and back again; and (x) gene x environment x development interaction.
本文提出了自杀行为的遗传和环境途径的初步类型学。提出并简要说明了十种途径：（i）精神障碍的直接影响；（ii）人格的直接影响；（iii）早期逆境的直接影响；（iv）当前逆境的直接影响；（v）基因对进入逆境的选择的直接影响（基因-环境相关性）；（vi）遗传风险与当前逆境之间的相互作用：基因-环境相互作用；（vii）早期和当前逆境之间的相互作用：环境-环境相互作用；（viii）文化与基因之间的相互作用；（ix）涉及从基因到环境再回到基因的因果循环的动态发展途径；和（x）基因 x 环境 x 发展相互作用。
