Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
School of Education, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J Affect Disord. 2019 Apr 15;249:104-111. doi: 10.1016/j.jad.2019.02.003. Epub 2019 Feb 6.
Suicide is the second leading cause of death among adolescents and young adults. Several studies have indicated significant genetic influences on suicide-related phenotypes and mounting evidence from neurobiological research has linked deficits in neurocognitive abilities to suicide phenotypes. The goal of the present study was to estimate the heritability of suicidal ideation (SI) in a large sample of adolescents and determine if SI is genetically correlated with neurocognitive functioning.
Genome-wide data (N = 3564 unrelated individuals of European Ancestry) were drawn from the Philadelphia Neurodevelopment Cohort. Adolescents completed a psychiatric assessment, as well as a computerized neurocognitive battery to assess performance across four domains: memory, executive function, social cognition, and complex cognition. Genomic-relatedness-matrix restricted maximum likelihood (GREML) estimation was used to determine SNP-heritability (h) of SI and the genetic correlation (r) between SI and neurocognitive domains.
Nearly 17% of adolescents reported SI. The SNP-heritability estimate for SI was marginally significant (h = 11%, SE = 8%, p = 0.086). Bivariate analyses indicated a significant r between SI and emotion identification (r = 0.79, SE = 0.45, p = 0.006; phenotypic correlation r = 0.04, p = 0.017).
It is possible that SI may represent a related, but differentially heritable construct from suicide attempts/completion and other comorbid psychopathology. Additionally, though genetic correlations point to shared genetic factors across traits, direct causal mechanisms cannot be deduced.
Common heritable factors contribute to variation in SI and neurocognitive functioning. Genetic factors influencing emotion identification have significant genetic overlap with SI.
自杀是青少年和年轻人的第二大死因。几项研究表明，自杀相关表型存在显著的遗传影响，神经生物学研究的越来越多证据表明，神经认知能力缺陷与自杀表型有关。本研究的目的是在一个大型青少年样本中估计自杀意念 (SI) 的遗传性，并确定 SI 是否与神经认知功能具有遗传相关性。
从费城神经发育队列中抽取了全基因组数据（N=3564 名无血缘关系的欧洲血统个体）。青少年完成了精神病学评估，以及计算机化的神经认知测试，以评估四个领域的表现：记忆、执行功能、社会认知和复杂认知。使用基因组相关矩阵限制最大似然估计 (GREML) 来确定 SI 的 SNP 遗传率 (h) 和 SI 与神经认知领域之间的遗传相关性 (r)。
近 17%的青少年报告有 SI。SI 的 SNP 遗传率估计值略高（h=11%，SE=8%，p=0.086）。双变量分析表明，SI 与情绪识别之间存在显著的 r（r=0.79，SE=0.45，p=0.006；表型相关 r=0.04，p=0.017）。
SI 可能代表与自杀企图/完成和其他共病精神病理学相关但遗传性不同的构念。此外，尽管遗传相关性表明性状之间存在共同的遗传因素，但不能推断直接的因果机制。
共同的遗传因素导致 SI 和神经认知功能的变化。影响情绪识别的遗传因素与 SI 具有显著的遗传重叠。
