Department of Clinical Pharmacy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Ther Drug Monit. 2010 Jun;32(3):269-72. doi: 10.1097/FTD.0b013e3181ddf717.
International guidelines do not recommend therapeutic drug monitoring (TDM) of HIV-infected children as a routine measurement as part of medical management. There are, however, several clinical scenarios in which TDM may be indicated. Underdosing may be one of the major risks, especially in younger children. No randomized controlled clinical trials have been conducted to assess the added value of TDM in HIV-infected children, making recommendations for TDM in children with HIV/AIDS merely based on expert opinion. There is a need for more descriptive studies on the usefulness of TDM in HIV-infected children to convince pediatricians worldwide to let more children benefit from TDM.
国际指南不建议将治疗药物监测（TDM）作为 HIV 感染儿童医疗管理的常规测量方法。然而，在某些临床情况下，TDM 可能是必要的。剂量不足可能是一个主要风险，尤其是在年幼的儿童中。目前尚未开展评估 TDM 在 HIV 感染儿童中附加价值的随机对照临床试验，因此，针对 HIV/AIDS 儿童的 TDM 建议仅基于专家意见。需要开展更多关于 TDM 在 HIV 感染儿童中有用性的描述性研究，以使全球儿科医生相信 TDM 可以使更多的儿童受益。
