细菌中转录后全局调控由 CsrA 完成。
Post-transcriptional global regulation by CsrA in bacteria.
机构信息
Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041, Gosselies, Belgium.
出版信息
Cell Mol Life Sci. 2010 Sep;67(17):2897-908. doi: 10.1007/s00018-010-0381-z. Epub 2010 May 6.
Abstract
Global regulation allows bacteria to rapidly modulate the expression of a large variety of unrelated genes in response to environmental changes. Global regulators act at different levels of gene expression. This review focuses on CsrA, a post-transcriptional regulator that affects translation of its gene targets by binding mRNAs. CsrA controls a large variety of physiological processes such as central carbon metabolism, motility and biofilm formation. The activity of CsrA is itself tightly regulated by the CsrB and CsrC small RNAs and the BarA-UvrY two-component system.
摘要
全球调控可使细菌迅速调节大量不相关基因的表达，以响应环境变化。全局调控因子在基因表达的不同水平起作用。本综述重点介绍 CsrA，这是一种通过结合 mRNA 来影响其靶基因翻译的转录后调控因子。CsrA 控制着包括中心碳代谢、运动性和生物膜形成在内的多种生理过程。CsrA 的活性本身受到 CsrB 和 CsrC 小 RNA 以及 BarA-UvrY 双组分系统的严格调控。
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